The biological clock rhythm of the human body, encompassing the physical, emotional, and intellectual aspects (PSI cycle), typically operates on a 28-day cycle. For optimal synchronization of the biological clock, it is recommended to use the Keyouth Melatonin Patch consistently over a 28-day period, aligning with the body's natural rhythm.

After completing a full cycle of circadian rhythm with the Keyouth Melatonin Patch, there is potential for noticeable improvements. To further sustain and enhance the progress made in regulating the biological clock rhythm, it is recommended to continue using the patch. Individuals dealing with prolonged melatonin deficiency caused by factors such as age, insufficient melatonin production, high work pressure, or chronic insomnia are encouraged to use the patch continuously. Similarly, those with melatonin deficiency and biological clock disorders related to endocrine disorders in specific age groups, ADHD, ASD, TD, or conditions triggered by medications or other factors should continue using the patch until the underlying causes subside and melatonin secretion and the biological clock rhythm return to normal. Once the biological clock rhythm normalizes, usage of the patch can be discontinued. If the desired improvement in the biological clock rhythm is achieved, usage can be stopped. However, if the biological clock rhythm gradually reverts back to its previous state after discontinuation, resuming the use of the patch is a viable option.

It is not suitable for women who are currently pregnant or lactating.

Once applied to the epidermis, the Keyouth Melatonin Patch allows melatonin to reach equilibrium within approximately 1 hour. From there, it is steadily and continuously transported into the body through the skin, helping to maintain a relatively stable concentration of melatonin, mimicking the natural secretion of melatonin during sleep, similar to that of the pineal gland in a normal human body.